What is the Zerial lab?
Our vision is to develop a systems understanding of the molecular mechanisms underlying cell and tissue organization. Over the years, we have been studying the molecular mechanisms of endocytosis, unravelling the key role played by Rab GTPases and their effectors. This work has led us to demonstrate that Rab5 is a master regulator of early endosome biogenesis. We have recently conducted a systems biology analysis by genome-wide RNAi screening in HeLa cells and in C. elegans, using quantitative multi-parametric image analysis (QMPIA). This led us to gain insights into the design principles of the endosomal system. We are now ready to apply this methodology to the multi-scale analysis of tissue organization and function. For general background information on our scientific interests, please visit our section dedicated to the public audience.
Fo was awarded the HFSP Long-Term Fellowship for his project on "Mapping the communication network between the endosomal system and cytoplasmic organelles" in mammalian cells. Congratulations, Fo! [Read more]
The European Research Council (ERC) announced the awarding of its prestigious Advanced Grants to 277 senior researchers. Among them is our project proposal "Rules of self-organization and reengineering of liver tissue"! [Read more]
In this review published in Current Opinions in Cell Biology we summarize recent studies that revealed the role of the endosomal network as a signal processing system. In particular, we discuss how the endosomal network resembles a digital-analogue computer by controlling the spatio-temporal regulation of signalling molecules. [Read more]