Principles of cell and tissue organization
MPI-CBG MPG
 

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Formation of macropinosomes in NIH3T3 cells

Formation of macropinosomes in NIH3T3 cells transiently co-expressing YFP-Rabankyrin-5 and CFP-b-actin. Membrane ruffling driven by actin results in the formation of large, plasma membrane derived vesicles acquiring Rabankyrin-5. Some newly formed vesicles shed off Rabankyrin-5 over time and seem to regurgitate back to the plasma membrane via an actin comet-tail.

Zerial lab
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