Latest News
In this study, we uncovered a new mechanism for how long tethering proteins can capture a vesicle and overcome their length to allow for more efficient membrane fusion. [Read more]
Fo was awarded the HFSP Long-Term Fellowship for his project on "Mapping the communication network between the endosomal system and cytoplasmic organelles" in mammalian cells. Congratulations, Fo! [Read more]
The European Research Council (ERC) announced the awarding of its prestigious Advanced Grants to 277 senior researchers. Among them is our project proposal "Rules of self-organization and reengineering of liver tissue"! [Read more]
In this review published in Current Opinions in Cell Biology we summarize recent studies that revealed the role of the endosomal network as a signal processing system. In particular, we discuss how the endosomal network resembles a digital-analogue computer by controlling the spatio-temporal regulation of signalling molecules. [Read more]
The Media Technologies and Outreach Department at MPI-CBG launched the "MPI-CBG Science Spotlights" introducing various research groups of the Institute. Click here if you want to know more about Marino and the research in our lab. [Read more]
In this study published in eLife we developed a pipeline for the reconstruction and quantitative analysis of tissue architecture in 3D. Using a combination of newly developed and stablished image analysis algorithms, our pipeline allows for a flexible workflow to reconstruct the different structures forming the tissue with superior accuracy. [Read more]
Fo was awarded the EMBO Long-Term Fellowship to elucidate the communication network scheme between the endosomal system and cytoplasmic organelles at membrane contact sites. Congratulations, Fo! [Read more]
In this study we used a combination of imaging, quantitative microscopy analysis and modeling to investigate the role of APPL1 in early endosomes. [Read more]
David Murray, our postdoc, attended the EMBO meeting on “The multidisciplinary era of endocytotic mechanics and functions”, last September 27 - October 2, in Mandelieu-La-Napoule, France. He presented his work on endosome tethering and won a best poster award. [Read more]
In this study we performed a compound library screen on two well-established siRNA delivery systems, lipid nanoparticles (LNPs) and cholesterol conjugated-siRNAs. We identified fifty-one enhancers improving gene silencing by 2 to 5 fold. Strikingly, most enhancers displayed specificity for one delivery system only. By a combination of quantitative fluorescence and electron microscopy we found that the enhancers substantially differed in their mechanism of action, increasing either the endocytic uptake or release of siRNAs from endosomes. [Read more]
Anja has been in our lab since October 2007 and worked on the connection between endosomal transport, cell polarity and metabolism in the liver. She discovered the necessity of the small GTPase Rab5 for endosomal biogenesis and gluconeogenic gene expression. [Read more]
In this study we uncovered a novel requirement of Rab5 and the endosomal system for the regulation of hepatic metabolism that goes beyond the classical view of controlling surface expression of nutrient transporters. [Read more]
This study highlights the strength of integrating chemical and functional genomics screens to gain insight into the mode of action of compounds. We screened a novel small molecule library in a degranulation and in a high-content image-based endocytosis assay used for computational analysis [Read more]
In this study we analyzed the spatial and temporal distribution of activated EGFR (p-EGFR) using novel quantitative microscopy methods. We found that p-EGFR is not randomly distributed but packaged at constant amounts in individual endosomes, resembling intracellular signalling "quanta". [Read more]
Marino was invited to participate to an event hosted by the President of the Italian Senate Pietro Grasso at Palazzo Giustiniani and organized by the Fondazione Armenise-Harvard and Senator Elena Cattaneo, on November 10, 2014 in Rome. [Read more]
In this study we reported for the first time a biochemical and functional characterization of the CORVET complex in mammalian cells. Similarly to the yeast ortholog, mammalian CORVET is a six-subunit complex effector of the small GTPase Rab5, and is required for endosome tethering and maturation. [Read more]
Anne did her PhD in the lab of Prof. Anders Tengholm at the Department of Medical Cell Biology, Uppsala University, Sweden. [Read more]
This month we had one more departure from the lab. Our postdoc, Hidenori Nonaka completed his work in the Zerial lab and returned to Japan. [Read more]
We are sad to say goodbye to our postdoc, Varadha, but also happy to see him moving on to his next career step as a group leader at the National Centre for Biological Sciences (NCBS) in Bangalore, India. [Read more]
We are happy to welcome Fabián Segovia Miranda to our team. Fabián did his PhD in the lab of Dr. Alfonso González de la Rosa, at the Pontificia Universidad Católica de Chile. [Read more]
Our job opening in Cell Biology of Infectious Diseases is now closed and we would like to welcome Nirmalya Basu to our team, who was hired to work on this project. [Read more]
Read what Gianluca, the designer of the website, wrote about the mosaic symbol and the selection of lively colors. [Read more]
We are hiring a postdoc in computational biology to work on 1)The development and implementation of algorithms and tools for the analysis of image-based genomic functional screens and/or 2) The 3D reconstruction and image analysis of liver tissue. For more information, please visit our job offer section. [Read more]
We are hiring a postdoc in the field of cell biology of infectious diseases to work on the in vivo pathogenesis of Mycobacterium tuberculosis. For more information, please visit our job offer section. [Read more]
The next Selection of the IMPRS PhD Program will take place on the first week of February 2014. Do not forget to register before November, 17. http://www.imprs-celldevosys.de/ [Read more]
Marino will talk about systems biology approaches to study endocytosis at the EMBO meeting on Systems Dynamics in Endocytosis, in Villars, Switzerland. [Read more]
