A multiparametric study of host-microbial interactions
In this study, we infected human primary macrophages with mycobacteria and monitored the response of both the bacteria and host cells to pharmocological compounds. We selected compounds that influence intracellular bacterial survival by modulating the host pathways and we developed novel computational approaches to identify the cellular mechanism of actions of these compounds. Our findings can be used to predict the mechanism of action of chemical compounds against pathogens beyond mycobacteria. Read more here.